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Genomics. 1989 Jul;5(1):160-2.

Localization of the gene for uridine monophosphate synthase to human chromosome region 3q13 by in situ hybridization.

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Department of Biochemical and Clinical Pharmacology, St. Jude Children's Research Hospital, Memphis 38101.


The bifunctional enzyme uridine monophosphate (UMP) synthase catalyzes the last two steps in de novo pyrimidine biosynthesis. A genetic deficiency in the activity of this enzyme causes the inherited human disease orotic aciduria. We used a human cDNA probe to localize the gene for UMP synthase to human chromosome region 3q13 by the technique of in situ hybridization.

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