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Cytokine. 2016 Dec;88:222-231. doi: 10.1016/j.cyto.2016.09.016. Epub 2016 Sep 24.

A randomized controlled trial examining the effects of 16 weeks of moderate-to-intensive cycling and honey supplementation on lymphocyte oxidative DNA damage and cytokine changes in male road cyclists.

Author information

1
Department of Sports Medicine, Justus-Liebig-University, Giessen, Germany. Electronic address: hajizadeh.sci.phys@gmail.com.
2
Department of Sport Injuries, Faculty of Physical Education and Sport Sciences, Allameh Tabataba'i University, Tehran, Iran. Electronic address: ba.tartibian@gmail.com.
3
Department of Sports Medicine, Justus-Liebig-University, Giessen, Germany. Electronic address: frank-christoph.mooren@sport.uni-giessen.de.
4
Department of Sports Medicine, Justus-Liebig-University, Giessen, Germany. Electronic address: Karsten.Krueger@sport.uni-giessen.de.
5
Department of Nursing, Mount Saint Mary's University, Los Angeles, CA, United States. Electronic address: lfitzgerald@msmu.edu.
6
Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Electronic address: mohamadchehrazi@gmail.com.

Abstract

The aim of this study was to investigate whether honey supplementation (70g, ninety minutes before each training session) attenuates changes in lymphocyte counts, DNA damage, cytokines, antioxidative and peroxidative biomarkers following moderate-to-intensive exercise training in male road cyclists. Healthy nonprofessional cyclists (n=24, aged 17-26years) were randomly assigned to exercise+supplement (EX+S, n=12) and exercise (EX, n=12) groups for an experimental period of 16weeks. Moderate-to-intensive exercise training increased lymphocytes DNA damage, cytokines and peroxidative biomarkers as well as decreased antioxidative biomarkers in the EX group. These changes were significantly attenuated in the EX+S group. Furthermore, for both groups the observed changes in peroxidative and antioxidative biomarkers could be correlated positively and negatively, respectively, with lymphocyte DNA damage and cytokines. Findings suggest that honey attenuates oxidative stress and lymphocyte DNA damage after exercise, activities that are most likely attributable to its high antioxidant capacity.

KEYWORDS:

DNA damage; Exercise training; Lymphocytes; Oxidative stress; Supplementation

PMID:
27676156
DOI:
10.1016/j.cyto.2016.09.016
[Indexed for MEDLINE]

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