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Front Physiol. 2016 Sep 12;7:381. doi: 10.3389/fphys.2016.00381. eCollection 2016.

Macropinocytosis Exploitation by Cancers and Cancer Therapeutics.

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Department of Anesthesia, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco San Francisco, CA, USA.


Macropinocytosis has long been known as a primary method for cellular intake of fluid-phase and membrane-bound bulk cargo. This review seeks to re-examine the latest studies to emphasize how cancers exploit macropinocytosis to further their tumorigenesis, including details in how macropinocytosis can be adapted to serve diverse functions. Furthermore, this review will also cover the latest endeavors in targeting macropinocytosis as an avenue for novel therapeutics.


altered membrane dynamics; macropinocytosis; macropinosome; neurodegenerative disease; pathogen entry; receptor-dependent macropinocytosis; targeted cancer therapy; tumor selective internalization

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