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Philos Trans R Soc Lond B Biol Sci. 2016 Nov 5;371(1707). pii: 20150504. doi: 10.1098/rstb.2015.0504.

When pathogenic bacteria meet the intestinal microbiota.

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Institut Pasteur, Unité des interactions Bactéries-Cellules, 75015 Paris, France Inserm, U604, 75015 Paris, France INRA, Unité sous contrat 2020, 75015 Paris, France
Institute for Biomedical Sciences, Center for Inflammation, Immunity, and Infection, Georgia State University, Atlanta, GA 30303, USA


The intestinal microbiota is a large and diverse microbial community that inhabits the intestinal tract, containing about 100 trillion bacteria from 500-1000 distinct species that, collectively, provide multiple benefits to the host. The gut microbiota contributes to nutrient absorption and maturation of the immune system, and also plays a central role in protection of the host from enteric bacterial infection. On the other hand, many enteric pathogens have developed strategies in order to be able to outcompete the intestinal community, leading to infection and/or chronic diseases. This review will summarize findings describing the complex relationship occurring between the intestinal microbiota and enteric pathogens, as well as how future therapies can ultimately benefit from such discoveries.This article is part of the themed issue 'The new bacteriology'.


inflammation; intestinal microbiota; nutrient; pathogenic bacteria; virulence

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