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Med Sci Sports Exerc. 2017 Feb;49(2):231-237. doi: 10.1249/MSS.0000000000001104.

Combined Exercise Training Improves Glycemic Control in Adult with Cystic Fibrosis.

Author information

1
1Institut de Recherches Cliniques de Montreal (IRCM), Montreal, Quebec, CANADA; 2Cystic Fibrosis Clinic, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, CANADA; 3Department of Nutrition, Montreal University, Montreal, Quebec, CANADA; and 4Department of Medecine, Montreal University, Montreal, Quebec, CANADA.

Abstract

PURPOSE:

Glucose abnormality and diabetes are the most common comorbidities in cystic fibrosis (CF). Combined (aerobic and resistance) exercise program in type 2 patients with diabetes demonstrated an improvement of glycemic control. The aim of the study was to determine whether a combined exercise program is beneficial to improve plasma glucose at 2 h of the oral glucose tolerance test in CF.

METHOD:

Eighteen adults with CF with glucose abnormality were recruited (Clinicaltrial.gov: NTC02127957), and 17 were randomly assigned to a control or exercise group for 12 wk. V˙O2max, oral glucose tolerance test, muscular endurance and strength, and quality of life were measured pre- and postintervention.

RESULTS:

Fourteen participants completed the protocol. Patients in the exercise group improved significantly their 2-h plasma glucose values (-2.34 ± 1.26 mmol·L, P < 0.007, confidence interval = 99.22%) and presented a reduction of 17.2% (P < 0.05) in total glucose excursion. No significant change for other parameters was observed.

CONCLUSION:

A combined exercise program improves glycemic control in CF.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT02127957.

PMID:
27669451
DOI:
10.1249/MSS.0000000000001104
[Indexed for MEDLINE]

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