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Curr Opin Neurobiol. 2016 Dec;41:136-148. doi: 10.1016/j.conb.2016.09.002. Epub 2016 Sep 23.

Olfactory circuits and behaviors of nematodes.

Author information

1
Department of Microbiology, Immunology, and Molecular Genetics University of California, Los Angeles, Los Angeles, CA 90095, United States.
2
Department of Microbiology, Immunology, and Molecular Genetics University of California, Los Angeles, Los Angeles, CA 90095, United States. Electronic address: ehallem@ucla.edu.

Abstract

Over one billion people worldwide are infected with parasitic nematodes. Many parasitic nematodes actively search for hosts to infect using volatile chemical cues, so understanding the olfactory signals that drive host seeking may elucidate new pathways for preventing infections. The free-living nematode Caenorhabditis elegans is a powerful model for parasitic nematodes: because sensory neuroanatomy is conserved across nematode species, an understanding of the microcircuits that mediate olfaction in C. elegans may inform studies of olfaction in parasitic nematodes. Here we review circuit mechanisms that allow C. elegans to respond to odorants, gases, and pheromones. We also highlight work on the olfactory behaviors of parasitic nematodes that lays the groundwork for future studies of their olfactory microcircuits.

PMID:
27668755
PMCID:
PMC5123917
DOI:
10.1016/j.conb.2016.09.002
[Indexed for MEDLINE]
Free PMC Article

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