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Nat Microbiol. 2016 Sep 26;1:16176. doi: 10.1038/nmicrobiol.2016.176.

Co-transfer of blaNDM-5 and mcr-1 by an IncX3-X4 hybrid plasmid in Escherichia coli.

Sun J1,2, Yang RS1,2, Zhang Q3, Feng Y4, Fang LX1,2, Xia J1,2, Li L1,2, Lv XY1,2, Duan JH1,2, Liao XP1,2, Liu YH1,2,5.

Author information

1
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China.
2
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
3
Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA.
4
Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Zhejiang 310027, China.
5
Jiangsu Co-Innovation Centre for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu 225009, China.

Abstract

Carbapenem and colistin are the last-resort antibiotics used for treating multidrug-resistant Gram-negative pathogens. Here, we report, for the first time, co-transfer of resistance to both classes of antibiotics by a mobile IncX3-X4 hybrid plasmid in an Escherichia coli isolate. Spread of such a plasmid is of great concern for clinical therapy, and heightened efforts are needed to control its dissemination.

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