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Pathog Immun. 2016 Spring;1(1):154-164.

A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?

Author information

1
Case Western Reserve University School of Medicine, Cleveland, OH.
2
University of Southern California, Los Angeles, CA.
3
University of California, Los Angeles, Los Angeles, CA.
4
University of Pennsylvania, Philadelphia, PA.
5
Fred Hutchinson Cancer Research Center, Seattle, WA.
6
The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital; Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia.
7
University of North Carolina at Chapel Hill, Chapel Hill, NC.
8
University of California, San Francisco, San Francisco, CA.
9
University of Pittsburgh, Pittsburgh, PA.
10
University of Minnesota, Minneapolis, MN.
11
Harvard University and Massachusetts Institute of Technology, Cambridge, MA.
12
Vaccine Research Center, National Institutes of Health, Bethesda, MD.

Abstract

With the advent and stunning success of combination antiretroviral therapy (ART) to prolong and improve quality of life for persons with HIV infection, HIV research has been afforded the opportunity to pivot towards studies aimed at finding "a cure." The mere idea that cure of HIV might be possible has energized researchers and the community towards achieving this goal. Funding agencies, both governmental and private, have targeted HIV cure as a high priority; many in the field have responded to these initiatives and the cure research agenda is robust. In this "salon" two editors of Pathogens and Immunity, Michael Lederman and Daniel Douek ask whether curing HIV is a realistic, scalable objective. We start with an overview perspective and have asked a number of prominent HIV researchers to add to the discussion.

KEYWORDS:

Berlin Patient; CCR5; HIV; cure; elite controller; eradication; functional cure; inflammation; latency; procoagulant; reservoir

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