Format

Send to

Choose Destination
Ann Transl Med. 2016 Aug;4(16):308. doi: 10.21037/atm.2016.07.15.

Effectiveness of enteral feeding protocol on clinical outcomes in critically ill patients: a study protocol for before-and-after design.

Author information

1
Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China ;
2
Department of Critical Care Medicine, Zhejiang Provincial People's Hospital, Hangzhou 310000, China ;
3
Department of Critical Care Medicine, Huzhou Central Hospital, Hangzhou 310000, China ;
4
Department of Critical Care Medicine, Zhejiang Provincial Hospital of TCM, Hangzhou 310000, China ;
5
Department of Critical Care Medicine, Shaoxing People's Hospital, Shaoxing 312000, China ;
6
Department of Critical Care Medicine, Yiwu Central Hospital, Yiwu 322000, China ;
7
Department of Critical Care Medicine, Ningbo First Hospital, Ningbo 315000, China ;
8
Department of Critical Care Medicine, Taizhou Hospital, Taizhou 318000, China ;
9
Department of Critical Care Medicine, Quzhou People's Hospital, Quzhou 324000, China ;
10
Department of Critical Care Medicine, Lishui People's Hospital, Lishui 323000, China.

Abstract

INTRODUCTION:

Enteral feed is an important component of nutritional therapy in critically ill patients and underfeeding has been associated with adverse outcomes. The article developed an enteral feeding protocol and planed a before-and-after comparative trial to explore whether implementation of enteral feeding protocol was able to improve clinical outcomes.

METHODS AND ANALYSIS:

The study will be conducted in intensive care units (ICUs) of ten tertiary care academic centers. Critically ill patients expected to stay in ICU for over 3 days and require enteral nutrition (EN) were potentially eligible. This is a before-and-after study comprising three phases: The first phase is the period without enteral feeding protocol; the second phase involves four-week training program, and the last phase is to perform the protocol in participating centers. We plan to enroll a total of 350 patients to provide an 80% power and 0.05 error rate to detect a 15% reduction of mortality. The primary outcome is 28-day mortality.

ETHICS AND DISSEMINATION:

Ethical approval to conduct the research has been obtained from all participating centers. Additionally, the results will be published in peer-reviewed journal.

TRIAL REGISTRATION:

The study was registered at International Standard Registered Clinical/soCial sTudy Number (ISRCTN) registry (ISRCTN10583582).

KEYWORDS:

Enteral feeding; intensive care unit (ICU); mortality; prospective; protocol

Supplemental Content

Full text links

Icon for AME Publishing Company Icon for PubMed Central
Loading ...
Support Center