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Biosci Biotechnol Biochem. 2017 Feb;81(2):372-375. doi: 10.1080/09168451.2016.1230007. Epub 2016 Sep 26.

The effects on plasma L-arginine levels of combined oral L-citrulline and L-arginine supplementation in healthy males.

Author information

1
a Healthcare Products Development Center , KYOWA HAKKO BIO CO.,LTD , Tsukuba , Japan.
2
b Division of Health Science , Nagoya University Graduate School of Medicine , Nagoya , Japan.

Abstract

We investigated the effects of combining 1 g of l-citrulline and 1 g of l-arginine as oral supplementation on plasma l-arginine levels in healthy males. Oral l-citrulline plus l-arginine supplementation more efficiently increased plasma l-arginine levels than 2 g of l-citrulline or l-arginine, suggesting that oral l-citrulline and l-arginine increase plasma l-arginine levels more effectively in humans when combined.

KEYWORDS:

combination effect; l-arginine, l-citrulline, human; oral intake

PMID:
27667025
DOI:
10.1080/09168451.2016.1230007
[Indexed for MEDLINE]

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