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Eur J Radiol. 2016 Oct;85(10):1867-1874. doi: 10.1016/j.ejrad.2016.08.014. Epub 2016 Aug 23.

Prediction of the therapeutic response after FOLFOX and FOLFIRI treatment for patients with liver metastasis from colorectal cancer using computerized CT texture analysis.

Author information

1
Department of Radiology, Seoul National University Hospital, Seoul, South Korea. Electronic address: joa0827@gmail.com.
2
Department of Radiology, Seoul National University Hospital, Seoul, South Korea; Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: jhkim2008@gmail.com.
3
Department of Radiology, Seoul National University Hospital, Seoul, South Korea; Cancer Research Institute, Seoul National University, Seoul, South Korea. Electronic address: lunao78@naver.com.
4
Department of Radiology, Seoul National University Hospital, Seoul, South Korea; Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: hanjk@snu.ac.kr.

Abstract

PURPOSE:

To determine whether baseline CT texture analysis of hepatic metastasis from colorectal cancer (CRC) is predictive of therapeutic response after cytotoxic chemotherapy.

MATERIALS AND METHODS:

235 patients with liver metastasis from CRC who underwent CT and cytotoxic chemotherapy using FOLFOX and FOLFIRI were divided into derivation cohort (n=145) and validation cohort (n=90). The CT texture of the hepatic metastasis was quantified using baseline CT. We analyzed the independent predictor for the response from derivation cohort and validated it using validation cohort. We also compared texture features between included four CT scanners.

RESULTS:

89 responding and 146 non-responding patients were evaluated. In the derivation cohort, lower skewness (OR, 6.739) in 2D, higher mean attenuation (OR, 2.587), and narrower standard deviation (SD) (OR, 3.163) in 3D were independently associated with response to chemotherapy. However, only lower skewness (P=0.213) on 2D and narrower SD on 3D analysis (P=0.097) did not show a significant difference on either CT scanner. When applied to the validation set, the lower skewness on 2D (AUC=0.797) and narrower SD on 3D (AUC=0.785) showed good performance.

CONCLUSION:

CT texture analysis is useful for prediction of therapeutic response after cytotoxic chemotherapy in patients with liver metastasis from colorectal cancer.

KEYWORDS:

CT; Cytotoxic chemotherapy; Hepatic metastasis from colorectal cancer; Texture analysis; Therapeutic response

PMID:
27666629
DOI:
10.1016/j.ejrad.2016.08.014
[Indexed for MEDLINE]

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