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J Obstet Gynaecol. 2017 Jan;37(1):19-24. doi: 10.1080/01443615.2016.1196480. Epub 2016 Sep 25.

Congenital cystic adenomatoid malformation of the lung (CCAM), a retrospective clinical audit and literature review in a tertiary centre in Scotland over a period of 14 years.

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a Department of Obstetrics & Gynaecology , Queens Mother's Hospital , Glasgow , UK (Now Merged with Southern General Hospital, Glasgow).


This work was a retrospective audit of CCAM - 1994 to 2008. A total of 26 cases were identified. Mean gestational age at diagnosis was 20 weeks. All were unilateral and had serial scans. In 31% the lesion resolved, 8% decreased, 42% were unchanged and 4% increased in size. Only one foetus developed hydrops. All were born alive. Of 8 foetuses where the CCAM was thought to have resolved, 6 had persistent lesions (overall sensitivity and PPV of US 64% and 69%, respectively). Computerised tomography performed better than chest X-ray in detecting lesions postnatally (sensitivity 100% vs 88%, PPV 95% vs 78%). Seventeen cases required surgery, 4 conservative management and 2 were discharged following negative CXR; 12% had associated anomalies. Four babies had recurrent chest infections. CCAMs have a good overall prognosis. CT scan rather than CXR should be performed to confirm the resolution of antenatally diagnosed lesions. Surgical management is the preferred option over conservative management.


Bronchopulmonary sequestration; congenital bronchopulmonary malformation; congenital cystic adenomatoid malformation of lung; pulmonary hypoplasia

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