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Hear Res. 2017 Apr;347:47-55. doi: 10.1016/j.heares.2016.08.018. Epub 2016 Sep 23.

Circadian regulation of auditory function.

Author information

1
Department of Physiology and Pharmacology, Laboratory of Experimental Audiology, Karolinska Institutet, 171 77 Stockholm, Sweden.
2
Department of Physiology and Pharmacology, Laboratory of Experimental Audiology, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Otolaryngology, Ajou University School of Medicine, 164, Worldcup-ro, Yeongtong-gu, Suwon, 16499, South Korea.
3
Department of Physiology and Pharmacology, Laboratory of Experimental Audiology, Karolinska Institutet, 171 77 Stockholm, Sweden. Electronic address: Barbara.Canlon@ki.se.

Abstract

The circadian system integrates environmental cues to regulate physiological functions in a temporal fashion. The suprachiasmatic nucleus, located in the hypothalamus, is the master clock that synchronizes central and peripheral organ clocks to orchestrate physiological functions. Recently, molecular clock machinery has been identified in the cochlea unravelling the potential involvement in the circadian regulation of auditory functions. Here, we present background information on the circadian system and review the recent findings that introduce circadian rhythms to the auditory field. Understanding the mechanisms by which circadian rhythms regulate auditory function will provide fundamental knowledge on the signalling networks that control vulnerability and resilience to auditory insults.

PMID:
27665709
PMCID:
PMC5364078
DOI:
10.1016/j.heares.2016.08.018
[Indexed for MEDLINE]
Free PMC Article

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