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Biochim Biophys Acta. 2016 Nov;1859(11):1440-1448. doi: 10.1016/j.bbagrm.2016.09.005. Epub 2016 Sep 21.

Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes.

Author information

1
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki 00290, Finland; Institute of Biotechnology, University of Helsinki, 00014, Finland.
2
Department of Functional Genomics and Cancer, Institute for genetics, molecular and cellular biology (IGBMC), Strasbourg 67404, France.
3
Medicum, Department of Biochemistry and Developmental Biology, University of Helsinki, Helsinki FIN-00014, Finland.
4
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki 00290, Finland.
5
Institute of Biotechnology, University of Helsinki, 00014, Finland.
6
National Institute for Health and Welfare (THL), Helsinki 00271, Finland.
7
Institute of Biotechnology, University of Helsinki, 00014, Finland; Institute of Clinical Medicine, Sognsvannsveien 20, Rikshospitalet, 0372 Oslo, Norway.
8
National Institute for Health and Welfare (THL), Helsinki 00271, Finland; Department of Virology, University of Turku, Turku 20014, Finland.
9
Department of Functional Genomics and Cancer, Institute for genetics, molecular and cellular biology (IGBMC), Strasbourg 67404, France. Electronic address: egly@igbmc.fr.
10
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki 00290, Finland. Electronic address: denis.kainov@helsinki.fi.

Abstract

Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication.

KEYWORDS:

Antiviral responses; Influenza A virus; Innate immunity; Regulation of gene expression; Viral counter-responses

PMID:
27664935
DOI:
10.1016/j.bbagrm.2016.09.005
[Indexed for MEDLINE]

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