Format

Send to

Choose Destination
Cell Biochem Funct. 1989 Apr;7(2):105-9.

Prostaglandin derivatives inhibit the growth of malarial parasites in mice.

Author information

1
Membrane Research Institute, University City Science Center, Philadelphia, PA.

Abstract

New prostaglandin oligomeric derivatives, termed MR-256 and MR-356, were found to inhibit the growth of murine malarial parasites, P. chabaudi and P. vinckei, within red blood cells in vivo. When mice were infected with P. chabaudi, both MR-256 and MR-356 suppressed the growth of parasites, but MR-356 had a greater inhibitory effect than MR-256. With P. vinckei, MR-356 also inhibited the growth of parasites, and improved the survival rate. The effect of MR-256 was much less. A possible inhibitory mechanism of action of these drugs is discussed.

PMID:
2766469
DOI:
10.1002/cbf.290070205
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center