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Genome Biol Evol. 2016 Dec 14;8(11):3297-3300.

Draft Genome Sequence of an Aflatoxigenic Aspergillus Species, A. bombycis.

Author information

1
Southern Regional Research Center, Agricultural Research Service, United States Department of Agriculture geromy.moore@ars.usda.gov.
2
Southern Regional Research Center, Agricultural Research Service, United States Department of Agriculture.

Abstract

Aspergillus bombycis was first isolated from silkworm frass in Japan. It has been reportedly misidentified as A. nomius due to their macro-morphological and chemotype similarities. We sequenced the genome of the A. bombycis Type strain and found it to be comparable in size (37 Mb), as well as in numbers of predicted genes (12,266), to other sequenced Aspergilli. The aflatoxin gene cluster in this strain is similar in size and the genes are oriented the same as other B- + G-aflatoxin producing species, and this strain contains a complete but nonfunctional gene cluster for the production of cyclopiazonic acid. Our findings also showed that the A. bombycis Type strain contains a single MAT1-2 gene indicating that this species is likely heterothallic (self-infertile). This draft genome will contribute to our understanding of the genes and pathways necessary for aflatoxin synthesis as well as the evolutionary relationships of aflatoxigenic fungi.

KEYWORDS:

Aspergillus bombycis; aflatoxins; genome sequence; mating-type locus; phylogenomics

PMID:
27664179
PMCID:
PMC5203779
DOI:
10.1093/gbe/evw238
[Indexed for MEDLINE]
Free PMC Article

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