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J Atten Disord. 2018 Feb;22(3):203-228. doi: 10.1177/1087054716669589. Epub 2016 Sep 1.

Adult ADHD and Comorbid Somatic Disease: A Systematic Literature Review.

Author information

1
1 Department of Biomedicine, University of Bergen, Norway.
2
3 K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Norway.
3
2 Department of Global Public Health and Primary Care, University of Bergen, Norway.
4
4 Norwegian Institute of Public Health, Bergen, Norway.
5
5 Haukeland University Hospital, Bergen, Norway.
6
6 Department of Clinical Medicine, University of Bergen, Norway.

Abstract

OBJECTIVE:

To systematically review, synthesize, and appraise available evidence, connecting adult ADHD with somatic disease.

METHOD:

Embase, Psychinfo, and Medline databases were searched for studies published from 1994 to 2015 addressing adult ADHD and somatic comorbidity. Somatic conditions were classified according to International Classification of Diseases (ICD-10) codes. Levels of evidence were graded as inconclusive, tentative, or well documented.

RESULTS:

Most of the 126 studies included in the qualitative synthesis were small and of modest quality. Obesity, sleep disorders, and asthma were well-documented comorbidities in adult ADHD. Tentative evidence was found for an association between adult ADHD and migraine and celiac disease. In a large health registry study, cardiovascular disease was not associated with adult ADHD.

CONCLUSION:

There are few large systematic studies using standardized diagnostic criteria evaluating adult ADHD and somatic comorbidities. Significant associations are found between adult ADHD and several somatic diseases, and these are important to consider when assessing and treating either adult ADHD or the somatic diseases.

KEYWORDS:

adult ADHD; asthma; migraine; review; sleep disorders

PMID:
27664125
PMCID:
PMC5987989
DOI:
10.1177/1087054716669589
[Indexed for MEDLINE]
Free PMC Article

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