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Curr Diab Rep. 2016 Nov;16(11):110.

Restoring Regulatory T Cells in Type 1 Diabetes.

Author information

1
Department of Surgery and UCSF Diabetes Center, University of California, 513 Parnassus HSE-520, Box 0780, San Francisco, CA, 94143, USA.
2
Department of Surgery and UCSF Diabetes Center, University of California, 513 Parnassus HSE-520, Box 0780, San Francisco, CA, 94143, USA. Qizhi.tang@ucsf.edu.

Abstract

Genetic and cellular studies of type 1 diabetes in patients and in the nonobese diabetic mouse model of type 1 diabetes point to an imbalance between effector T cells and regulatory T cells (Tregs) as a driver of the disease. The imbalance may arise as a consequence of genetically encoded defects in thymic deletion of islet antigen-specific T cells, induction of islet antigen-specific thymic Tregs, unfavorable tissue environment for peripheral Treg induction, and failure of islet antigen-specific Tregs to survive in the inflamed islets secondary to insufficient IL-2 signals. These understandings are the foundation for rationalized design of new therapeutic interventions to restore the balance by selectively targeting effector T cells and boosting Tregs.

KEYWORDS:

CTLA-4; IL-2; Nonobese diabetic (NOD) mice; Regulatory T cells (Tregs); Therapy; Type 1 diabetes

PMID:
27664043
DOI:
10.1007/s11892-016-0807-6
[Indexed for MEDLINE]
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