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Obesity (Silver Spring). 2016 Nov;24(11):2344-2350. doi: 10.1002/oby.21649. Epub 2016 Sep 24.

Effects of a meal replacement system alone or in combination with phentermine on weight loss and food cravings.

Author information

1
Department of Psychology, School of Behavioral Health, Loma Linda University, Loma Linda, California, USA.
2
Department of Pharmaceutical and Administrative Sciences, School of Pharmacy, Loma Linda University, Loma Linda, California, USA.
3
Department of Allied Health Studies, School of Allied Health Professions, Loma Linda University, Loma Linda, California, USA.
4
Department of Nutrition and Dietetics, School of Allied Health Professions, Loma Linda University, Loma Linda, California, USA.
5
Department of Pathology and Human Anatomy, Loma Linda University, Loma Linda, California, USA.
6
Department of Physical Therapy, School of Allied Health Professions, Loma Linda University, Loma Linda, California, USA.
7
Department of Preventative Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA.. wpeters@llu.edu.

Abstract

OBJECTIVE:

To examine the effects of phentermine combined with a meal replacement program on weight loss and food cravings and to investigate the relationship between food cravings and weight loss.

METHODS:

In a 12-week randomized, double-blind, placebo-controlled clinical trial, 77 adults with obesity received either phentermine or placebo. All participants were provided Medifast® meal replacements, were instructed to follow the Take Shape for Life® Optimal Weight 5&1 Plan for weight loss, and received lifestyle coaching in the Habits of Health program. The Food Craving Inventory and the General Food Cravings State and Trait Questionnaires were used to measure food cravings.

RESULTS:

The phentermine group lost 12.1% of baseline body weight compared with 8.8% in the placebo group. Cravings for all food groups decreased in both groups; however, there was a greater reduction in cravings for fats and sweets in the phentermine group compared with the placebo group. Percent weight loss correlated significantly with reduced total food cravings (r = 0.332, P = 0.009), cravings for sweets (r = 0.412, P < 0.000), and state food cravings (r = 0.320, P = 0.007).

CONCLUSIONS:

Both phentermine combined with a meal replacement program and meal replacements alone significantly reduced body weight and food cravings; however, the addition of phentermine enhanced these effects.

PMID:
27664021
DOI:
10.1002/oby.21649
[Indexed for MEDLINE]
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