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Cell Chem Biol. 2016 Sep 22;23(9):1044-1046. doi: 10.1016/j.chembiol.2016.09.005.

Lipase Processing of Complex Lipid Antigens.

Author information

1
Institute of Medical Microbiology, University of Zurich, Gloriastrasse 30/32, CH-8006 Zurich, Switzerland. Electronic address: psander@imm.uzh.ch.
2
Institute of Medical Microbiology, University of Zurich, Gloriastrasse 30/32, CH-8006 Zurich, Switzerland.

Abstract

Mycobacterium tuberculosis synthesizes a wide variety of complex lipids that can serve as antigens in immune recognition of the bacterium. In this issue of Cell Chemical Biology, Gilleron et al. (2016) identify key enzymes essential for lipid antigen processing, which is required for CD1b-restricted T cell activation.

PMID:
27662250
DOI:
10.1016/j.chembiol.2016.09.005
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