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Curr Opin Genet Dev. 2016 Dec;41:98-105. doi: 10.1016/j.gde.2016.08.007. Epub 2016 Sep 20.

Recent advances in the study of fine-scale population structure in humans.

Author information

1
Department of Human Genetics, University of Chicago, IL 60636, United States; Department of Ecology and Evolutionary Biology, University of Chicago, IL 60636, United States.
2
Department of Human Genetics, University of Chicago, IL 60636, United States.

Abstract

Empowered by modern genotyping and large samples, population structure can be accurately described and quantified even when it only explains a fraction of a percent of total genetic variance. This is especially relevant and interesting for humans, where fine-scale population structure can both confound disease-mapping studies and reveal the history of migration and divergence that shaped our species' diversity. Here we review notable recent advances in the detection, use, and understanding of population structure. Our work addresses multiple areas where substantial progress is being made: improved statistics and models for better capturing differentiation, admixture, and the spatial distribution of variation; computational speed-ups that allow methods to scale to modern data; and advances in haplotypic modeling that have wide ranging consequences for the analysis of population structure. We conclude by outlining four important open challenges: the limitations of discrete population models, uncertainty in individual origins, the incorporation of both fine-scale structure and ancient DNA in parametric models, and the development of efficient computational tools, particularly for haplotype-based methods.

PMID:
27662060
PMCID:
PMC5291306
DOI:
10.1016/j.gde.2016.08.007
[Indexed for MEDLINE]
Free PMC Article

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