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Gene. 2016 Dec 20;595(1):31-38. doi: 10.1016/j.gene.2016.09.028. Epub 2016 Sep 19.

RAB23, regulated by miR-92b, promotes the progression of esophageal squamous cell carcinoma.

Author information

1
Department of Gastroenterology, People's Hospital of Zhengzhou University (Henan Provincial People's Hospital), Henan Province, China.
2
Department of Gastroenterology, People's Hospital of Zhengzhou University (Henan Provincial People's Hospital), Henan Province, China. Electronic address: zzlixiuling01@aliyun.com.

Abstract

RAB23, a member of Ras-related small GTPase family, has been reported to be up-regulated in several cancer types. However, its biological functions and the underlying molecular mechanisms for its oncogenic roles in esophageal squamous cell carcinoma (ESCC) remain unknown. In this study, we have shown that the expression of RAB23 was elevated in ESCC tissues and ESCC cells. Overexpression of RAB23 promoted the growth and migration of the ESCC cells, while knocking down the expression RAB23 inhibited the growth, migration and metastasis of the ESCC cells. The molecular mechanism study showed that RAB23 activated beta-catenin/TCF signaling and regulated the expression of several target genes. In the further study, it was found that the expression of RAB23 was regulated by the miR-92b. Forced expression of MiR-92b decreased the mRNA and protein level of RAB23, and RAB23 rescued the biological functions of miR-92b. Taken together, this study revealed the oncogenic roles and the regulation of RAB23 in ESCC, suggesting RAB23 might be a therapeutic target.

KEYWORDS:

Beta-catenin/TCF signaling; Cell growth and migration; ESCC; RAB23; miR-92b

PMID:
27659550
DOI:
10.1016/j.gene.2016.09.028
[Indexed for MEDLINE]

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