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Curr Diab Rep. 2016 Nov;16(11):104. doi: 10.1007/s11892-016-0798-3.

Urinary Proteomics for Diagnosis and Monitoring of Diabetic Nephropathy.

Author information

1
Institute of Cardiovascular and Medical Sciences, University of Glasgow, 126 University Place, Glasgow, G12 8TA, UK. Gemma.Currie@glasgow.ac.uk.
2
Institute of Cardiovascular and Medical Sciences, University of Glasgow, 126 University Place, Glasgow, G12 8TA, UK.

Abstract

The last decade has seen a surge in publications describing novel biomarkers for early detection of diabetic nephropathy (DN), but as yet none have outperformed albuminuria in well-designed prospective studies. This is partially attributable to our incomplete understanding of the many complex interrelated mechanisms underlying DN development, a heterogeneous process unlikely to be captured by a single biomarker. Proteomics offers the advantage of simultaneously analysing the entire protein content of a biological sample, and the technique has gained attention as a potential tool for a more accurate diagnosis of disease at an earlier stage as well as a means by which to unravel the pathogenesis of complex diseases such as DN using an untargeted approach. This review will discuss the potential of proteomics as both a clinical and research tool, evaluating exploratory work in animal models as well as diagnostic potential in human subjects.

KEYWORDS:

Biomarkers; Diabetes; Nephropathy; Proteomics; Translational

PMID:
27658932
DOI:
10.1007/s11892-016-0798-3
[Indexed for MEDLINE]

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