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Nat Rev Cancer. 2016 Nov;16(11):732-749. doi: 10.1038/nrc.2016.89. Epub 2016 Sep 23.

The multifaceted roles of fatty acid synthesis in cancer.

Author information

1
Department of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, Am Hubland, 97074 Würzburg, Germany.
2
Comprehensive Cancer Center Mainfranken, Josef-Schneider-Strasse 6, 97080 Würzburg, Germany.

Abstract

Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular process that converts nutrients into metabolic intermediates for membrane biosynthesis, energy storage and the generation of signalling molecules. This Review explores how different aspects of FA synthesis promote tumorigenesis and tumour progression. FA synthesis has received substantial attention as a potential target for cancer therapy, but strategies to target this process have not yet translated into clinical practice. Furthermore, efforts to target this pathway must consider the influence of the tumour microenvironment.

PMID:
27658529
DOI:
10.1038/nrc.2016.89
[Indexed for MEDLINE]

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