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Neuron. 2016 Sep 21;91(6):1199-1218. doi: 10.1016/j.neuron.2016.09.006.

Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline.

Author information

1
Medical Scientist Training Program, Program in Neuroscience, Department of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address: elizabeth.ballinger@stonybrookmedicine.edu.
2
Program in Neuroscience, Department of Neurobiology & Behavior, Department of Psychiatry & Behavioral Science, Stony Brook University, Stony Brook, NY 11794, USA.
3
Department of Pharmacological Sciences, CNS Disorders Center, Center for Molecular Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
4
Department of Neurobiology & Behavior, Neurosciences Institute, CNS Disorders Center, Center for Molecular Medicine, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address: lorna.role@stonybrook.edu.

Abstract

Recent work continues to place cholinergic circuits at center stage for normal executive and mnemonic functioning and provides compelling evidence that the loss of cholinergic signaling and cognitive decline are inextricably linked. This Review focuses on the last few years of studies on the mechanisms by which cholinergic signaling contributes to circuit activity related to cognition. We attempt to identify areas of controversy, as well as consensus, on what is and is not yet known about how cholinergic signaling in the CNS contributes to normal cognitive processes. In addition, we delineate the findings from recent work on the extent to which dysfunction of cholinergic circuits contributes to cognitive decline associated with neurodegenerative disorders.

PMID:
27657448
PMCID:
PMC5036520
DOI:
10.1016/j.neuron.2016.09.006
[Indexed for MEDLINE]
Free PMC Article

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