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J Neurophysiol. 2016 Dec 1;116(6):2647-2655. doi: 10.1152/jn.00588.2016. Epub 2016 Sep 21.

Edge orientation signals in tactile afferents of macaques.

Author information

1
Committee on Computational Neuroscience, University of Chicago, Chicago, Illinois; and.
2
Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois.
3
Committee on Computational Neuroscience, University of Chicago, Chicago, Illinois; and sliman@uchicago.edu.

Abstract

The orientation of edges indented into the skin has been shown to be encoded in the responses of neurons in primary somatosensory cortex in a manner that draws remarkable analogies to their counterparts in primary visual cortex. According to the classical view, orientation tuning arises from the integration of untuned input from thalamic neurons with aligned but spatially displaced receptive fields (RFs). In a recent microneurography study with human subjects, the precise temporal structure of the responses of individual mechanoreceptive afferents to scanned edges was found to carry information about their orientation. This putative mechanism could in principle contribute to or complement the classical rate-based code for orientation. In the present study, we further examine orientation information carried by mechanoreceptive afferents of Rhesus monkeys. To this end, we record the activity evoked in cutaneous mechanoreceptive afferents when edges are indented into or scanned across the skin. First, we confirm that information about the edge orientation can be extracted from the temporal patterning in afferent responses of monkeys, as is the case in humans. Second, we find that while the coarse temporal profile of the response can be predicted linearly from the layout of the RF, the fine temporal profile cannot. Finally, we show that orientation signals in tactile afferents are often highly dependent on stimulus features other than orientation, which complicates putative decoding strategies. We discuss the challenges associated with establishing a neural code at the somatosensory periphery, where afferents are exquisitely sensitive and nearly deterministic.

PMID:
27655968
PMCID:
PMC5133299
DOI:
10.1152/jn.00588.2016
[Indexed for MEDLINE]
Free PMC Article

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