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J Neurol Sci. 2016 Oct 15;369:121-125. doi: 10.1016/j.jns.2016.08.012. Epub 2016 Aug 5.

Lobar intracerebral haematomas: Neuropathological and 7.0-tesla magnetic resonance imaging evaluation.

Author information

1
Université Lille 2, INSERM U1171, Degenerative & vascular cognitive disorders, CHU Lille, F-59000 Li, France. Electronic address: dereuck.j@gmail.com.
2
Université Lille 2, INSERM U1171, Degenerative & vascular cognitive disorders, CHU Lille, F-59000 Li, France.

Abstract

BACKGROUND AND PURPOSE:

The Boston criteria for cerebral amyloid angiopathy (CAA) need validation by neuropathological examination in patients with lobar cerebral haematomas (LCHs). In "vivo" 1.5-tesla magnetic resonance imaging (MRI) is unreliable to detect the age-related signal changes in LCHs. This post-mortem study investigates the validity of the Boston criteria in brains with LCHs and the signal changes during their time course with 7.0-tesla MRI.

MATERIALS AND METHODS:

Seventeen CAA brains including 26 LCHs were compared to 13 non-CAA brains with 14 LCHs. The evolution of the signal changes with time was examined in 25 LCHs with T2 and T2* 7.0-tesla MRI.

RESULTS:

In the CAA group LCHs were predominantly located in the parieto-occipital lobes. Also white matter changes were more severe with more cortical microinfarcts and cortical microbleeds. On MRI there was a progressive shift of the intensity of the hyposignal from the haematoma core in the acute stage to the boundaries later on. During the residual stage the hyposignal mildly decreased in the boundaries with an increase of the superficial siderosis and haematoma core collapse.

CONCLUSIONS:

Our post-mortem study of LCHs confirms the validity of the Boston criteria for CAA. Also 7.0-tesla MRI allows staging the age of the LCHs.

KEYWORDS:

Boston criteria; Cerebral amyloid angiopathy; Haematoma aging; Lobar cerebral haematoma; Neuropathology; Post-mortem 7.0-tesla MRI

PMID:
27653876
DOI:
10.1016/j.jns.2016.08.012
[Indexed for MEDLINE]

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