Format

Send to

Choose Destination
Immunity. 2016 Sep 20;45(3):471-482. doi: 10.1016/j.immuni.2016.09.001.

Germinal Center B Cell Dynamics.

Author information

1
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
2
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. Electronic address: victora@rockefeller.edu.

Abstract

Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in the past 10 years, with a succession of findings that have transformed our understanding of the cellular dynamics of affinity maturation. In this review, we discuss recent developments in the field, with special emphasis on how GC cellular and clonal dynamics shape antibody affinity and diversity during the immune response.

PMID:
27653600
PMCID:
PMC5123673
DOI:
10.1016/j.immuni.2016.09.001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center