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Mol Cell Oncol. 2016 Mar 30;3(4):e1169343. doi: 10.1080/23723556.2016.1169343. eCollection 2016 Jul.

BRCA1-CtIP interaction in the repair of DNA double-strand breaks.

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The Institute for Cancer Genetics, Columbia University , New York, NY, USA.


DNA termini at double-strand breaks are often chemically heterogeneous and require processing before initiation of repair. In a recent report, we demonstrated that CtIP and the MRE11-RAD50-NBS1 (MRN) nuclease complex cooperate with BRCA1 to specifically repair topoisomerase II-DNA adducted breaks. In contrast, BRCA1 is dispensable for repair of restriction endonuclease-generated double-strand breaks.


DNA damage and repair; DNA double-strand breaks; DNA end resection; homologous recombination; topoisomerases

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