Format

Send to

Choose Destination
  • PMID: 27651544 was deleted because it is a duplicate of PMID: 28191771
Stem Cells Transl Med. 2017 Feb;6(2):335-339. doi: 10.5966/sctm.2015-0225. Epub 2016 Sep 20.

Linking Pluripotency Reprogramming and Cancer.

Author information

1
Synpromics Ltd., Edinburgh, United Kingdom.
2
StemTek Therapeutics, Bilbao, Spain.

Abstract

Tumor development and the generation of induced pluripotent stem cells are highly comparable processes with striking similarities. Cellular plasticity is inherent to tumor evolution, rendering cells that acquire a stem cell-like phenotype, for which Sox2 activation has proved instrumental for the plastic acquisition of stemness properties in tumor cells. Understanding the molecular mechanisms underlying both events might uncover novel approaches for the development of anticancer therapeutics and constitute model systems for understanding tumor generation and ensuring the biosafety of cell-based therapies. Stem Cells Translational Medicine 2017;6:335-339.

PMID:
28191771
PMCID:
PMC5442824
DOI:
10.5966/sctm.2015-0225

Supplemental Content

Loading ...
Support Center