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J Nutr Biochem. 2016 Nov;37:94-100. doi: 10.1016/j.jnutbio.2016.07.015. Epub 2016 Aug 26.

Effects of hydroxytyrosol on cardiovascular biomarkers in experimental diabetes mellitus.

Author information

1
Departmento de Farmacología, Facultad de Medicina, Instituto de Investigación Biomédica (IBIMA), Universidad de Málaga.
2
Instituto de la Grasa, Consejo Superior de Investigaciones Científicas (CSIC), Ctra Utrera km 1, Campus Universitario Pablo de Olavide, Edificio 46, Seville, Spain.
3
Departmento de Farmacología, Facultad de Medicina, Instituto de Investigación Biomédica (IBIMA), Universidad de Málaga. Electronic address: correa@uma.es.

Abstract

The aim of this study was to assess the influence of hydroxytyrosol (HT) on cardiovascular biomarkers and morphometric parameters of the arterial wall in streptozotocin-diabetic rats. Seven groups of rats (N=10 per group) were studied for 2 months: nondiabetic rats (NDR), diabetic rats treated with saline (DR) and DR treated with HT (0.5, 1, 2.5, 5 and 10 mg kg-1 day-1 p.o.). DR had higher platelet aggregation values, higher thromboxane B2, plasma lipid peroxidation, 3-nitrotyrosine, oxidized LDL (oxLDL), myeloperoxidase, vascular cell adhesion molecule 1 (VCAM-1) and interleukin-1β (IL-1β) concentrations, and lower aortic 6-keto-prostaglandin F and nitric oxide production than NDR. Aortic wall area and smooth muscle cell count were also higher in DR than in NDR. HT significantly reduced both oxidative and nitrosative stress, oxLDL concentration, VCAM-1 and inflammatory mediators, platelet aggregation and thromboxane B2 production. Morphometric values in the aortic wall were reduced to values near those in NDR. In conclusion, HT influenced the major biochemical processes leading to diabetic vasculopathy, and reduced cell proliferation in the vascular wall in this experimental model.

KEYWORDS:

Diabetes; Hydroxytyrosol; Inflammatory mediators; Oxidative stress; Platelets; Vasculopathy

PMID:
27648880
DOI:
10.1016/j.jnutbio.2016.07.015
[Indexed for MEDLINE]

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