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Mol Psychiatry. 2017 Mar;22(3):476-482. doi: 10.1038/mp.2016.149. Epub 2016 Sep 20.

Depression, daily stressors and inflammatory responses to high-fat meals: when stress overrides healthier food choices.

Author information

1
Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, USA.
2
Department of Psychiatry and Behavioral Health, The Ohio State University College of Medicine, Columbus, OH, USA.
3
Department of Psychology, Rice University, Houston, TX, USA.
4
Department of Symptoms Research, MD Anderson Cancer Center, Houston, TX, USA.
5
Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH, USA.
6
Center for Biostatistics, The Ohio State University, Columbus, OH, USA.
7
Department of Medicine, The Ohio State University Medical Center, Columbus, OH, USA.
8
Health and Rehabilitation Sciences, The Ohio State University Medical Center, Columbus, OH, USA.
9
Department of Human Sciences, College of Education and Human Ecology, The Ohio State University, Columbus, OH, USA.

Abstract

Depression, stress and diet can all alter inflammation. This double-blind, randomized crossover study addressed the impact of daily stressors and a history of major depressive disorder (MDD) on inflammatory responses to high-fat meals. During two separate 9.5 h admissions, 58 healthy women (38 breast cancer survivors and 20 demographically similar controls), mean age 53.1 years, received either a high saturated fat meal or a high oleic sunflower oil meal. The Daily Inventory of Stressful Events assessed prior day stressors and the Structured Clinical Interview for DSM-IV evaluated MDD. As expected, for a woman with no prior day stressors, C-reactive protein (CRP), serum amyloid A (SAA), intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) were higher following the saturated fat meal than the high oleic sunflower oil meal after controlling for pre-meal measures, age, trunk fat and physical activity. But if a woman had prior day stressors, these meal-related differences disappeared-because the stressors heightened CRP, SAA, sICAM-1 and sVCAM-1 responses to the sunflower oil meal, making it look more like the responses to the saturated fat meal. In addition, women with an MDD history had higher post-meal blood pressure responses than those without a similar history. These data show how recent stressors and an MDD history can reverberate through metabolic alterations, promoting inflammatory and atherogenic responses.

PMID:
27646264
PMCID:
PMC5508550
DOI:
10.1038/mp.2016.149
[Indexed for MEDLINE]
Free PMC Article

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