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Br J Pharmacol. 2017 Jun;174(11):1226-1243. doi: 10.1111/bph.13627. Epub 2016 Oct 25.

Effects of anthocyanins on the prevention and treatment of cancer.

Author information

1
Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai, China.
2
Key Laboratory of Arrhythmias, Ministry of Education (Tongji University), Shanghai, China.
3
Institute of Medical Genetics, Tongji University School of Medicine, Shanghai, China.

Abstract

Anthocyanins are a class of water-soluble flavonoids, which show a range of pharmacological effects, such as prevention of cardiovascular disease, obesity control and antitumour activity. Their potential antitumour effects are reported to be based on a wide variety of biological activities including antioxidant; anti-inflammation; anti-mutagenesis; induction of differentiation; inhibiting proliferation by modulating signal transduction pathways, inducing cell cycle arrest and stimulating apoptosis or autophagy of cancer cells; anti-invasion; anti-metastasis; reversing drug resistance of cancer cells and increasing their sensitivity to chemotherapy. In this review, the latest progress on the anticancer activities of anthocyanins and the underlying molecular mechanisms is summarized using data from basic research in vitro and in vivo, from clinical trials and taking into account theory and practice.

LINKED ARTICLES:

This article is part of a themed section on Principles of Pharmacological Research of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.11/issuetoc.

PMID:
27646173
PMCID:
PMC5429338
DOI:
10.1111/bph.13627
[Indexed for MEDLINE]
Free PMC Article

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