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FEBS Lett. 2016 Nov;590(22):4084-4104. doi: 10.1002/1873-3468.12424. Epub 2016 Oct 6.

Enhancers and their dynamics during hematopoietic differentiation and emerging strategies for therapeutic action.

Author information

1
Inserm UMR967, CEA/DRF/iRCM, Fontenay-aux-Roses, France.
2
CNRS, Institute of Molecular Genetics (IGMM), Montpellier, France.
3
Laboratory of Excellence GR-Ex, Paris, France.

Abstract

Cellular differentiation requires precisely regulated tissue-specific and developmental stage-specific gene expression patterns. Numerous studies have highlighted the predictive power of enhancers on lineage-specific gene expression programs and have started to unravel their mechanisms of action. We review here the dynamics of the enhancer landscape during hematopoietic differentiation and how enhancers function in the context of the 3D organization of the genome. We further discuss the involvement of aberrant enhancer activity in human diseases and emerging strategies aiming at controlling enhancer activity and chromosome topology for therapeutic purposes.

KEYWORDS:

3D genome organization; chromatin looping; enhancer; hematopoiesis; transcription factors

PMID:
27645909
DOI:
10.1002/1873-3468.12424
[Indexed for MEDLINE]
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