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Curr Opin Genet Dev. 2016 Dec;41:77-84. doi: 10.1016/j.gde.2016.08.005. Epub 2016 Sep 16.

The African diaspora: history, adaptation and health.

Author information

1
Center for Research on Genomics and Global Health National Human Genome Research Institute, Building 12A, Room 4047 12 South Drive, Bethesda, MD 20892, USA. Electronic address: rotimic@mail.nih.gov.
2
Center for Research on Genomics and Global Health National Human Genome Research Institute, Building 12A, Room 4047 12 South Drive, Bethesda, MD 20892, USA.

Abstract

The trans-Atlantic slave trade brought millions of Africans to the New World. Advances in genomics are providing novel insights into the history and health of Africans and the diasporan populations. Recent examples reviewed here include the unraveling of substantial hunter-gatherer and 'Eurasian' admixtures across sub-Saharan Africa, expanding our understanding of ancestral African genetics; the global ubiquity of mixed ancestry; the revealing of African ancestry in Latin Americans that likely derived from the slave trade; and understanding of the ancestral backgrounds of APOL1 and LPL found to influence kidney disease and lipid levels, respectively, providing specific insights into disease etiology and health disparities.

PMID:
27644073
PMCID:
PMC5318189
DOI:
10.1016/j.gde.2016.08.005
[Indexed for MEDLINE]
Free PMC Article

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