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Macromol Rapid Commun. 2016 Dec;37(23):1952-1959. doi: 10.1002/marc.201600353. Epub 2016 Sep 19.

Exploiting Bisphosphonate-Bioactive-Glass Interactions for the Development of Self-Healing and Bioactive Composite Hydrogels.

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Department of Biomaterials, Radboud University Medical Center, 6525, EX, Nijmegen, The Netherlands.
Institute of Organic and Macromolecular Chemistry, Heinrich-Heine-University Düsseldorf, 40225, Düsseldorf, Germany.
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, 3508, TB, Utrecht, The Netherlands.
Department of Materials Chemistry, Angstrom Laboratory, A Science for Life Laboratory, Uppsala University, SE 75121, Uppsala, Sweden.
Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, 91058, Erlangen, Germany.


Hydrogels are widely recognized as promising candidates for various biomedical applications, such as tissue engineering. Recently, extensive research efforts have been devoted to the improvement of the biological and mechanical performance of hydrogel systems by incorporation of functional groups and/or inorganic particles in their composition. Bisphosphonates are a class of drugs, commonly used for treatment of osteoporosis, which exhibit a strong binding affinity for hydroxyapatite. In this study, the binding affinity of a bisphosphonate-functionalized polymer, hyaluronan, toward a bioactive glass (i.e., 45S5 Bioglass) is evaluated using force-distance measurements with atomic force microscopy. The strong interaction between bisphosphonate and bioactive glass is then exploited to develop organic-inorganic composite hydrogels and the viscoelastic and self-healing ability of these materials are investigated. Finally, the stability and mineralization behavior of these hydrogels are evaluated in simulated body fluid. Following this approach, injectable, bioactive and self-healing organic-inorganic composite hydrogels are produced, which mineralize abundantly and rapidly in simulated body fluid. These properties render these composite gels suitable for applications in bone-tissue engineering.


bioactive glasses; bisphosphonates; hydrogels; self-healing; tissue engineering

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