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J Agric Food Chem. 2016 Oct 12;64(40):7475-7480. Epub 2016 Sep 27.

Benzophenones from Mango Leaves Exhibit α-Glucosidase and NO Inhibitory Activities.

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School of Pharmacy, Guangdong Pharmaceutical University , 280 East Outer Ring Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica, State Administration of TCM , Guangzhou 510006, China.


Mango (Mangifera indica L.) is a succulent tropical fruit. Bioactive phytochemical investigation has been carried out to the leaves of mango. Three new benzophenone glycosides, along with 14 known compounds, were purified and identified. The novel benzophenones were elucidated to be 2,4,4',6-tetrahydroxy-3'-methoxybenzophenone-3-C-β-d-glucopyranoside (1), 4,4',6-trihydroxybenzophenone-2-O-α-l-arabinofuranoside (7), and 4',6-dihydroxy-4-methoxybenzophenone-2-O-(2″),3-C-(1″)-1″-desoxy-α-l-fructofuranoside (11). The α-glucosidase inhibitory, NO production inhibitory, and antioxidant activities were assessed for the purified benzophenones and triterpenoids. Some benzophenones showed moderate α-glucosidase and NO inhibitory activities. The IC50 value of the α-glucosidase inhibitory of isolated compounds 1, 13, and 14 were 284.93 ± 20.29, 239.60 ± 25.00, and 297.37 ± 8.12 μM, respectively. Most compounds showed moderate effects to reduce the NO content in 50 and 100 μM. The above results of bioactivity powerfully demonstrated the phytochemicals from mango, especially benzophenones, probably partially rational for its antidiabetes and anti-inflammatory.


Mangifera indica; anti-inflammatory; antioxidant; benzophenones; mango; α-glucosidase inhibitory

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