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Nat Neurosci. 2016 Nov;19(11):1523-1536. doi: 10.1038/nn.4393. Epub 2016 Sep 19.

Multimodal population brain imaging in the UK Biobank prospective epidemiological study.

Author information

1
Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, UK.
2
Department of Electrical Engineering, Brigham Young University, Provo, Utah, USA.
3
Institute of Neurology, University College London, London, UK.
4
Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA.
5
Icahn School of Medicine at Mount Sinai, New York, New York, USA.
6
Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany.
7
Siemens Healthcare UK, Frimley, UK.
8
UK Biobank, Stockport, UK.
9
Nuffield Department of Population Health, University of Oxford, Oxford, UK.
10
Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK.

Abstract

Medical imaging has enormous potential for early disease prediction, but is impeded by the difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to address this problem directly by acquiring high-quality, consistently acquired imaging data from 100,000 predominantly healthy participants, with health outcomes being tracked over the coming decades. The brain imaging includes structural, diffusion and functional modalities. Along with body and cardiac imaging, genetics, lifestyle measures, biological phenotyping and health records, this imaging is expected to enable discovery of imaging markers of a broad range of diseases at their earliest stages, as well as provide unique insight into disease mechanisms. We describe UK Biobank brain imaging and present results derived from the first 5,000 participants' data release. Although this covers just 5% of the ultimate cohort, it has already yielded a rich range of associations between brain imaging and other measures collected by UK Biobank.

PMID:
27643430
PMCID:
PMC5086094
DOI:
10.1038/nn.4393
[Indexed for MEDLINE]
Free PMC Article

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