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Nat Neurosci. 2016 Dec;19(12):1628-1635. doi: 10.1038/nn.4392. Epub 2016 Sep 19.

Dynamic GABAergic afferent modulation of AgRP neurons.

Author information

1
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
2
Centre for Integrative Physiology, Hugh Robson Building, University of Edinburgh, Edinburgh, UK.
3
Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
4
National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA.
5
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
6
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
7
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
8
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.

Abstract

Agouti-related peptide (AgRP) neurons of the arcuate nucleus of the hypothalamus (ARC) promote homeostatic feeding at times of caloric insufficiency, yet they are rapidly suppressed by food-related sensory cues before ingestion. Here we identify a highly selective inhibitory afferent to AgRP neurons that serves as a neural determinant of this rapid modulation. Specifically, GABAergic projections arising from the ventral compartment of the dorsomedial nucleus of the hypothalamus (vDMH) contribute to the preconsummatory modulation of ARCAgRP neurons. In a manner reciprocal to ARCAgRP neurons, ARC-projecting leptin receptor-expressing GABAergic vDMH neurons exhibit rapid activation upon availability of food that additionally reflects the relative value of the food. Thus, leptin receptor-expressing GABAergic vDMH neurons form part of the sensory network that relays real-time information about the nature and availability of food to dynamically modulate ARCAgRP neuron activity and feeding behavior.

PMID:
27643429
PMCID:
PMC5382799
DOI:
10.1038/nn.4392
[Indexed for MEDLINE]
Free PMC Article

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