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CPT Pharmacometrics Syst Pharmacol. 2016 Sep;5(9):449-51. doi: 10.1002/psp4.12109. Epub 2016 Sep 17.

GPS for QSP: A Summary of the ACoP6 Symposium on Quantitative Systems Pharmacology and a Stage for Near-Term Efforts in the Field.

Author information

1
Cardiovascular and Metabolic Diseases Research Unit, Pfizer Inc., Cambridge, Massachusetts, USA.
2
Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
3
Quantitative Pharmacology and Pharmacometrics, Merck Research Labs, Merck & Co, Rahway, New Jersey, USA.
4
Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
5
Quantitative Sciences, Janssen Research and Development, San Diego, California, USA. mzager1@its.jnj.com.

Abstract

Quantitative Systems Pharmacology (QSP) is experiencing increased application in the drug discovery and development process. Like its older sibling, systems biology, the QSP field is comprised of a mix of established disciplines and methods, from molecular biology to engineering to pharmacometrics. As a result, there exist critical segments of the discipline that differ dramatically in approach and a need to bring these groups together toward a common goal.

PMID:
27639191
PMCID:
PMC5036418
DOI:
10.1002/psp4.12109
[Indexed for MEDLINE]
Free PMC Article
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