Format

Send to

Choose Destination
Autoimmun Rev. 2016 Dec;15(12):1171-1180. doi: 10.1016/j.autrev.2016.09.003. Epub 2016 Sep 15.

The role of microRNAs in the pathogenesis of autoimmune diseases.

Author information

1
Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Móricz Zs. str. 22, H-4032 Debrecen, Hungary.
2
Centre for Immune Regulation, Department of Immunology, University of Oslo, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
3
Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Móricz Zs. str. 22, H-4032 Debrecen, Hungary. Electronic address: zeher@iiibel.dote.hu.

Abstract

MicroRNAs (miRNAs) are single-stranded, endogenous non-coding small RNAs, ranging from 18 to 25 nucleotides in length. Growing evidence suggests that miRNAs are essential in regulating gene expression, cell development, differentiation and function. Autoimmune diseases are a family of chronic systemic inflammatory diseases. Recent findings on miRNA expression profiles have been suggesting their role as biomarkers in autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis and Sjögren's syndrome. In this review, we summarize the characteristics of miRNAs and their functional role in the immune system and autoimmune diseases including systemic lupus erythematosus, primary Sjögren's syndrome, rheumatoid arthritis, systemic sclerosis, multiple sclerosis and psoriasis; moreover, we depict the advantages of miRNAs in modern diagnostics.

KEYWORDS:

MicroRNAs (miRs); Multiple sclerosis (MS); Primary Sjögren's syndrome (SS); Psoriasis; Rheumatoid arthritis (RA); Systemic lupus erythematosus (SLE); Systemic sclerosis (SSc)

PMID:
27639156
DOI:
10.1016/j.autrev.2016.09.003
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center