Mitochondrial Antigen Presentation: A Vacuolar Path to Autoimmunity in Parkinson's Disease

Pascale Baden; Michela Deleidi

doi:10.1016/j.it.2016.08.016

Mitochondrial Antigen Presentation: A Vacuolar Path to Autoimmunity in Parkinson's Disease

Trends Immunol. 2016 Nov;37(11):719-721. doi: 10.1016/j.it.2016.08.016. Epub 2016 Sep 13.

Authors

Pascale Baden¹, Michela Deleidi²

Affiliations

¹ German Centre for Neurodegenerative Diseases (DZNE) Tübingen within the Helmholtz Association, Tübingen, Germany; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
² German Centre for Neurodegenerative Diseases (DZNE) Tübingen within the Helmholtz Association, Tübingen, Germany; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. Electronic address: michela.deleidi@dzne.de.

PMID: 27638127
DOI: 10.1016/j.it.2016.08.016

Abstract

Mitochondrial antigens can be presented by MHC molecules and initiate adaptive immune responses but the mechanisms of mitochondrial antigen presentation (MitAP) have remained mostly unknown. A recent study proposes a new model whereby MitAP is mediated by a vesicle transport pathway that is suppressed by the Parkinson's disease (PD) associated proteins PTEN-induced putative kinase 1 (PINK1) and Parkin. This discovery brings a new perspective on the link between mitochondrial dysfunction and autoimmunity in PD.

Publication types

Comment

MeSH terms

Adaptive Immunity
Animals
Antigen Presentation*
Autoantigens / immunology
Autoantigens / metabolism*
Autoimmunity
Histocompatibility Antigens / metabolism
Humans
Mitochondria / immunology
Mitochondria / metabolism*
Models, Immunological
Parkinson Disease / immunology*
Protein Kinases / metabolism*
Protein Transport
Secretory Vesicles / metabolism*
Ubiquitin-Protein Ligases / metabolism*
Vacuoles / metabolism

Substances

Autoantigens
Histocompatibility Antigens
Ubiquitin-Protein Ligases
parkin protein
Protein Kinases
PTEN-induced putative kinase