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Trends Endocrinol Metab. 2016 Dec;27(12):881-892. doi: 10.1016/j.tem.2016.08.006. Epub 2016 Sep 13.

Sarcolipin: A Key Thermogenic and Metabolic Regulator in Skeletal Muscle.

Author information

1
Department of Physiology and Cell Biology, Ohio State University, Columbus, OH, USA.
2
Sanford Burnham Medical Research Institute at Lake Nona, Orlando, FL, USA; School of Biotechnology, KIIT University, Bhubaneswar, Odisha, India.
3
Department of Physiology and Cell Biology, Ohio State University, Columbus, OH, USA; Sanford Burnham Medical Research Institute at Lake Nona, Orlando, FL, USA. Electronic address: mperiasamy@spbdiscovery.org.

Abstract

Skeletal muscle constitutes ∼40% of body mass and has the capacity to play a major role as thermogenic, metabolic, and endocrine organ. In addition to shivering, muscle also contributes to nonshivering thermogenesis via futile sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) activity. Sarcolipin (SLN), a regulator of SERCA activity in muscle, plays an important role in regulating muscle thermogenesis and metabolism. Uncoupling of SERCA by SLN increases ATP hydrolysis and heat production, and contributes to temperature homeostasis. SLN also affects whole-body metabolism and weight gain in mice, and is upregulated in various muscle diseases including muscular dystrophy, suggesting a role for SLN during increased metabolic demand. In this review we also highlight the physiological roles of skeletal muscle beyond contraction.

KEYWORDS:

SERCA; metabolism; sarcolipin; skeletal muscle; thermogenesis

PMID:
27637585
PMCID:
PMC5424604
DOI:
10.1016/j.tem.2016.08.006
[Indexed for MEDLINE]
Free PMC Article

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