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J Am Chem Soc. 2016 Oct 19;138(41):13457-13460. doi: 10.1021/jacs.6b04464. Epub 2016 Oct 10.

Highly Sensitive Coherent Anti-Stokes Raman Scattering Imaging of Protein Crystals.

Author information

1
Joint Institute for Nuclear Research , 141980 Dubna, Russia.
2
Dubna State University , 19 Universitetskaya st., Dubna 141982, Russia.
3
SOL Instruments , 220005 BY P.O. Box 235, Minsk, Republic of Belarus.
4
Moscow Institute of Physics and Technology , 141700 Dolgoprudny, Moscow region, Russia.
5
Institut de Biologie Structurale J.-P. Ebel, Université Grenoble Alpes-CEA-CNRS , F-38000 Grenoble, France.
6
Institute of Complex Systems: Structural Biochemistry (ICS-6), Research Centre Jülich , 52425 Jülich, Germany.

Abstract

Serial crystallography at last generation X-ray synchrotron sources and free electron lasers enabled data collection with micrometer and even submicrometer size crystals, which have resulted in amazing progress in structural biology. However, imaging of small crystals, which although is highly demanded, remains a challenge, especially in the case of membrane protein crystals. Here we describe a new extremely sensitive method of the imaging of protein crystals that is based on coherent anti-Stokes Raman scattering.

PMID:
27636908
DOI:
10.1021/jacs.6b04464

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