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J Alzheimers Dis. 2017;55(1):359-369.

N-Terminal Pro-B Type Natriuretic Peptide is Associated with Mild Cognitive Impairment in the General Population.

Author information

1
Cardiovascular Center, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany.
2
West-German Heart and Vascular Center, Department of Cardiology, University of Duisburg-Essen, Essen, Germany.
3
Department of Neurology, University Hospital of Essen, University of Duisburg-Essen, Germany.
4
Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.
5
Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.

Abstract

BACKGROUND:

N-terminal pro-B type natriuretic peptide (NT-proBNP) is a marker of cardiac stress and is linked with silent cardiac diseases. While associations of cognitive impairment with manifest cardiovascular diseases are established, data on whether subclinical elevation of NT-proBNP levels below clinically established threshold of heart failure is related with cognitive functioning, especially mild cognitive impairment (MCI), is rare.

OBJECTIVE:

Aim of the present study was to investigate the cross-sectional association of NT-proBNP levels and MCI in a population-based study sample without heart failure.

METHODS:

We used data from the second examination of the population based Heinz-Nixdorf-Recall-Study. Subjects with overt coronary heart disease and subjects with NT-proBNP levels indicating potential heart failure (NT-proBNP≥300 pg/ml) were excluded from this analysis. Participants performed a validated brief cognitive assessment and were classified either as MCI [subtypes: amnestic-MCI (aMCI), non-amnestic-MCI (naMCI)], or cognitively-normal.

RESULTS:

We included 419 participants with MCI (63.1±7.4 y; 47% men; aMCI n = 209; naMCI n = 210) and 1,206 cognitively normal participants (62.42±7.1 y; 48% men). NT-proBNP-levels≥125 pg/ml compared to <125 pg/ml were associated with MCI in fully adjusted models (OR 1.65 (1.23;2.23) in the total sample, 1.73 (1.09;2.74) in men and 1.63(1.10;2.41) in women). For aMCI, the fully adjusted OR was 1.53 (1.04;2.25) and for naMCI, the fully adjusted OR was 1.34 (1.09; 166) in the total sample.

CONCLUSION:

Within normal ranges and without manifest heart failure, higher NT-proBNPlevels are associated with MCI and both MCI subtypes independent of traditional cardiovascular risk factors and sociodemographic parameters.

KEYWORDS:

Alzheimer’s disease; BNP; NT-proBNP; mild cognitive impairment; natriuretic peptides

PMID:
27636851
DOI:
10.3233/JAD-160635
[Indexed for MEDLINE]

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