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Int J Dent. 2016;2016:9868421. doi: 10.1155/2016/9868421. Epub 2016 Aug 21.

Erythritol Is More Effective Than Xylitol and Sorbitol in Managing Oral Health Endpoints.

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Cargill R&D Centre Europe, Havenstraat 84, 1800 Vilvoorde, Belgium.
Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, 20520 Turku, Finland.
Institute of Dentistry, Faculty of Medicine, University of Tartu, Raekoja Plats 6, 51003 Tartu, Estonia.
Equinox Scientific Services, 11-26520 Twp Road 512, Spruce Grove, AB, Canada T7Y 1G1.
Cargill Incorporated, 15407 McGinty Road West (MS-163), Wayzata, MN 55391, USA.



To provide a comprehensive overview of published evidence on the impact of erythritol, a noncaloric polyol bulk sweetener, on oral health.


A literature review was conducted regarding the potential effects of erythritol on dental plaque (biofilm), dental caries, and periodontal therapy. The efficacy of erythritol on oral health was compared with xylitol and sorbitol.


Erythritol effectively decreased weight of dental plaque and adherence of common streptococcal oral bacteria to tooth surfaces, inhibited growth and activity of associated bacteria like S. mutans, decreased expression of bacterial genes involved in sucrose metabolism, reduced the overall number of dental caries, and served as a suitable matrix for subgingival air-polishing to replace traditional root scaling.


Important differences were reported in the effect of individual polyols on oral health. The current review provides evidence demonstrating better efficacy of erythritol compared to sorbitol and xylitol to maintain and improve oral health.

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