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J Cereb Blood Flow Metab. 2016 Nov;36(11):1865-1871. Epub 2016 Sep 15.

Epidermal growth factor prevents oligomeric amyloid-β induced angiogenesis deficits in vitro.

Author information

1
Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.
2
Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA leontai@uic.edu.

Abstract

Cerebrovascular dysfunction is a critical component of Alzheimer's disease (AD) pathogenesis. Oligomeric amyloid-β42 (oAβ42) is considered a major contributor to AD progression. However, data are limited on the role of oAβ42 in brain endothelial cell vessel degeneration/angiogenesis, including the interaction with angiogenic mediators. Thus, the current study determined the effect of oAβ42 on angiogenesis in vitro, utilizing single brain endothelial cell cultures and triple cultures mimicking the microvascular unit (MVU: brain endothelial cells, astrocytes, and pericytes). oAβ42 dose-dependently reduced angiogenesis and induced vessel disruption. Critically, epidermal growth factor prevented oAβ42-induced deficits, implicating angiogenic pathways as potential therapeutics for AD.

KEYWORDS:

Alzheimer’s; angiogenesis; blood–brain barrier; cerebrovascular disease; endothelium; pericytes

PMID:
27634936
PMCID:
PMC5094316
DOI:
10.1177/0271678X16669956
[Indexed for MEDLINE]
Free PMC Article

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