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Oncotarget. 2016 Nov 8;7(45):73573-73592. doi: 10.18632/oncotarget.12017.

Flavan-3-ols consumption and cancer risk: A meta-analysis of epidemiologic studies.

Lei L1,2, Yang Y1,2, He H1,2, Chen E1,2, Du L1,2, Dong J1,2, Yang J1,2.

Author information

1
Key Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an 710069, China.
2
Institute of Preventive Genomic Medicine, Xi'an 710069, China.

Abstract

Although numerous in vitro studies and animal model data have suggested that flavan-3-ols, the most common subclass of flavonoids in the diet, may exert protective effects against cancer, epidemiologic studies have reported inconclusive results for the association between flavan-3-ols intake and cancer risk. Therefore, we conducted this meta-analysis of epidemiologic studies to investigate the preventive effects of flavan-3-ols on various types of cancers. A total of 43 epidemiologic studies, consisting of 25 case-control and 18 prospective cohort studies, were included. A significant inverse association was shown between flavan-3-ols intake and the risk of overall cancer (relative risk (RR) 0.935, 95%CI: 0.891-0.981). When cancer types were separately analyzed, a statistically significant protective effect of flavan-3-ols consumption was observed in rectal cancer (RR 0.838, 95%CI: 0.733-0.958), oropharyngeal and laryngeal cancer (RR 0.759, 95%CI: 0.581-0.993), breast (RR 0.885, 95%CI: 0.790-0.991) in case-control studies and stomach cancer in women (RR 0.633, 95%CI: 0.468-0.858). Our analysis indicates the potential benefits of flavan-3-ols in cancer prevention.

KEYWORDS:

breast cancer; cancer; colorectal cancer; flavan-3-ols; meta-analysis

PMID:
27634884
PMCID:
PMC5342000
DOI:
10.18632/oncotarget.12017
[Indexed for MEDLINE]
Free PMC Article

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