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Asian Pac J Trop Med. 2016 Sep;9(9):872-876. doi: 10.1016/j.apjtm.2016.07.009. Epub 2016 Jul 26.

CETP polymorphisms confer genetic contribution to centenarians of Hainan, south of China.

Author information

1
Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, Hainan Province, China.
2
Hainan Cadre Sanatorium/Geriatric Hospital of Hainan, Haikou, Hainan Province, China.
3
Department of Reproduction and Genetics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
4
Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, Hainan Province, China. Electronic address: caiww591020@163.com.

Abstract

OBJECTIVE:

In this paper, we will discuss if the CETP polymorphism contributes to the centenarians in Hainan island.

METHODS:

We tested the TaqIB and I405V polymorphisms of CETP gene among 276 centenarians and 301 matched healthy individuals by AS-PCR and analyzed the data with SPSS software package (Version 19.0).

RESULTS:

Our data indicated that allele B1 and V have the significant differences between centenarians and healthy control groups with P < 0.001. Further analysis implied that genotypes B1B1 (P < 0.001, OR = 0.148, 95% CI = 0.095-0.230) and VV (P < 0.001 and OR = 0.353, 95% CI = 0.237-0.525) were significantly different between centenarians and matched controls. The combination of B and V, such as B1B1-II (P < 0.001, OR = 0.128, 95% CI = 0.049-0.329), B1B1-IV (P < 0.001, OR = 0.115, 95% CI = 0.056-0.237), B1B2-VV (P < 0.05, OR = 0.534, 95% CI = 0.310-0.920), and B2B2-VV (P < 0.001, OR = 0.198, 95% CI = 0.086-0.453) have significant differences between centenarians and matched healthy individuals from Hainan.

CONCLUSION:

Our results implied that allele B1B1 and VV, as well as the combination B1B1-II, B1B1-IV, B1B2-VV and B2B2-VV may contribute to the longevity in centenarians of Hainan, south of China.

KEYWORDS:

Centenarians; Genetic contribution; Polymorphisms of CETP

PMID:
27633301
DOI:
10.1016/j.apjtm.2016.07.009
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