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Cell Res. 2016 Nov;26(11):1178-1179. doi: 10.1038/cr.2016.107. Epub 2016 Sep 16.

A new edge to immune surveillance by the neural system.

Author information

1
Department of Experimental Immunology, Academic Medical Center at the University of Amsterdam, Amsterdam, the Netherlands.
2
Tytgat Institute for liver and intestinal research, Academic Medical Center at the University of Amsterdam, Amsterdam, the Netherlands.

Abstract

A recent paper published in Nature demonstrates a multifaceted relation between enteric glial cells (EGC), intestinal epithelia, and ILC3, via the EGC release of neurotrophic factors, a structurally related group of ligands within the TGF-β superfamily of signaling molecules and IL-22 produced by ILC3.

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